Tacrolimus (Pangraf) blood level
Quick answer: This test measures the level of tacrolimus, a medicine that prevents organ rejection, in your blood. It is used regularly after a transplant and in some autoimmune conditions to keep the dose in a safe and effective range.
- SampleBlood
- TakesAbout 5 minutes
- Before the testThe sample is usually taken just before your next dose; follow your doctor's timing and do not change your dose on your own.
How the test is done
- 1You come for the test before taking your morning dose
- 2Staff note the time of your last dose
- 3Blood is drawn from a vein into a tube
- 4You take your dose after the sample, as your doctor advised
What your results can mean
Reading your report
Your doctor compares the level with the target range set for your treatment.
If the result is outside the usual range
A level above your target can be seen with dose changes, some other medicines or foods such as grapefruit, liver problems or diarrhoea, and can raise the risk of side effects. A level below target can raise the risk of rejection and may be seen with missed doses or interacting medicines.
Who usually has this test
People who have had a kidney, liver or other organ transplant, and some people with autoimmune conditions treated with tacrolimus.
Risks and aftercare
Minor bruising may occur; take your dose after the test as instructed.
Names and options
Also called: Pangraf level, tacrolimus trough, FK506 level
Listed by the hospital as
- PANGRAF LEVEL, EDTA
Questions about this test
What is a tacrolimus trough level?
A trough level is the lowest level in your blood, just before your next dose. Doctors use it because it gives a consistent reading to compare with your target.
What can change my tacrolimus level?
Many things can, including other medicines such as some antibiotics and antifungals, grapefruit, diarrhoea, liver problems and switching between brands. Always tell your transplant team about new medicines.
How often is a tacrolimus level checked?
Levels are checked often soon after a transplant or a dose change, and less often once stable. Your transplant team will set the schedule for you.
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This page explains each test in general terms so you know what to expect. It is not medical advice: your doctor decides which tests you need and what your results mean. Reference ranges differ between laboratories. Updated 4 November 2026.