PLA2R antibody test
Quick answer: This blood test looks for antibodies against PLA2R, which are found in most people with a kidney condition called primary membranous nephropathy. It is ordered when someone has heavy protein loss in the urine, and to monitor response to treatment.
- SampleBlood
- TakesAbout 5 minutes
- Before the testNo special preparation is usually needed.
How the test is done
- 1You are seated and a vein in your arm is cleaned
- 2A needle draws blood into a tube
- 3The lab tests the sample for antibodies to PLA2R
- 4Repeat tests may be done later to track treatment
What your results can mean
Reading your report
Normal ranges differ between labs, so compare your result with the range printed on your report and discuss it with your doctor.
If the result is outside the usual range
A positive result can point to primary membranous nephropathy, and falling levels can suggest the condition is responding to treatment. A negative result makes this cause less likely but does not rule it out.
Who usually has this test
Adults with heavy protein loss in the urine or nephrotic syndrome, and people already diagnosed with membranous nephropathy.
Risks and aftercare
Nothing special is needed afterwards apart from minor care of the needle site.
Names and options
Also called: anti-PLA2R, phospholipase A2 receptor antibody
Listed by the hospital as
- PLA2 ANTIBODY
Questions about this test
What is membranous nephropathy?
It is a kidney condition in which the filters of the kidney are damaged, causing heavy protein loss in the urine and often swelling. In many adults it is caused by antibodies against PLA2R.
Can the PLA2R test avoid a kidney biopsy?
In some people with typical features and a clearly positive result, doctors may decide a biopsy is not needed. This is a specialist decision based on your full picture.
Why is the PLA2R test repeated?
Antibody levels often fall before protein loss improves. Repeating the test helps the kidney specialist see whether treatment is working.
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This page explains each test in general terms so you know what to expect. It is not medical advice: your doctor decides which tests you need and what your results mean. Reference ranges differ between laboratories. Updated 4 November 2026.