Serum immunoelectrophoresis
Quick answer: This test separates the antibodies in your blood to look for an abnormal single type of antibody. Doctors order it to help diagnose myeloma and related conditions; immunofixation is now more often used.
- SampleBlood
- TakesAbout 5 minutes
- Before the testNo special preparation is usually needed.
How the test is done
- 1You sit and the inside of your elbow is cleaned
- 2A needle draws blood into a tube
- 3The lab separates your antibodies on a gel
- 4The pattern is checked for an abnormal single antibody band
What your results can mean
Reading your report
The report describes the protein pattern, so discuss it with your doctor.
If the result is outside the usual range
An abnormal band can point to myeloma, a related plasma cell condition, or a harmless condition called MGUS that needs monitoring. A normal pattern makes these less likely.
Who usually has this test
People with suspected myeloma or related conditions, such as those with bone pain, anaemia, kidney problems or raised globulin.
Risks and aftercare
Only a small bruise is likely.
Names and options
Also called: immuno electrophoresis, IEP
Listed by the hospital as
- IMMUNO ELECTROPHORESIS, SERUM
Questions about this test
How is immunoelectrophoresis different from immunofixation?
Both look for abnormal antibodies. Immunofixation is more sensitive and faster, so it is now used more often.
What is MGUS?
Monoclonal gammopathy of undetermined significance is a condition with a small abnormal antibody but no myeloma. It is usually watched with regular tests.
Is this test used to monitor myeloma?
It can help, but other tests such as protein electrophoresis and free light chains are more often used for follow-up.
Related tests
Tamara Hospital & IVF Centre, Rajajinagar
34/3, 10th Cross Road, opp. Vardhaka Sardar Patel School, 1st N Block, 2nd Stage, Rajajinagar, Bengaluru 560010
The hospital is open 24 hours. Call before you come to check the timing for your scan or sample collection.
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This page explains each test in general terms so you know what to expect. It is not medical advice: your doctor decides which tests you need and what your results mean. Reference ranges differ between laboratories. Updated 4 November 2026.