Factor V Leiden mutation test
Quick answer: This genetic test checks for factor V Leiden, an inherited change that makes blood more likely to clot. It is ordered after an unexplained blood clot, a clot at a young age, or with a strong family history of clots.
- SampleBlood
- TakesAbout 5 minutes
- Before the testNo special preparation is needed.
- In fertility careIt may be checked in women with a past clot before pregnancy or hormone treatment; most guidelines do not advise routine testing after miscarriage or IVF failure alone.
How the test is done
- 1Blood is drawn into an EDTA tube
- 2The lab extracts DNA from your white cells
- 3A genetic test looks for the factor V Leiden change
- 4The result shows no copy, one copy or two copies
What your results can mean
Reading your report
Results show whether you carry no copy, one copy or two copies of the change; discuss what this means with your doctor.
If the result is outside the usual range
One copy raises clot risk somewhat and two copies raise it more, especially with pregnancy, the contraceptive pill or surgery. A negative result means you do not carry this change, though other clot risks may exist.
Who usually has this test
People with unusual or repeated blood clots or a strong family history of clots, and some women with certain pregnancy complications.
Risks and aftercare
Bruising is possible; genetic counselling may help if you carry the change.
Names and options
Also called: FVL test, factor V Leiden, thrombophilia gene test
Listed by the hospital as
- FACTOR V LEIDEN MUTANT DETECTION
Questions about this test
Should all IVF patients be tested for factor V Leiden?
No, routine testing is not advised for everyone. It is usually for people with a personal or strong family history of clots.
Can blood thinners affect the factor V Leiden test?
No, this is a DNA test, so blood thinners and recent clots do not change the result. It only needs to be done once.
Does factor V Leiden cause miscarriage?
The evidence linking it to miscarriage is mixed. Your doctor will advise on whether treatment in pregnancy is needed.
Related tests
Tamara Hospital & IVF Centre, Rajajinagar
34/3, 10th Cross Road, opp. Vardhaka Sardar Patel School, 1st N Block, 2nd Stage, Rajajinagar, Bengaluru 560010
The hospital is open 24 hours. Call before you come to check the timing for your scan or sample collection.
Get directions ↗IVF Pulse fertility care at Tamara Hospital →
Reception
Waiting area
IVF lab
This page explains each test in general terms so you know what to expect. It is not medical advice: your doctor decides which tests you need and what your results mean. Reference ranges differ between laboratories. Updated 4 November 2026.