Beta-2 transferrin test
Quick answer: This test checks a fluid sample for beta-2 transferrin, a protein found almost only in the fluid around the brain and spine (CSF). Doctors order it when clear fluid drips from the nose or ear, to see if it is a CSF leak.
- SampleFluid
- TakesVaries; collecting enough fluid can take 15 minutes or more
- Before the testYour doctor will explain how to collect the dripping fluid.
How the test is done
- 1Your doctor explains how to collect the fluid dripping from your nose or ear
- 2You collect the fluid into a clean container, often by leaning forward
- 3A blood sample may also be taken for comparison
- 4The sample is sent to the lab promptly
What your results can mean
Reading your report
A positive result suggests the fluid is CSF, so discuss it with your doctor.
If the result is outside the usual range
A positive result suggests the fluid is cerebrospinal fluid, which means there may be a leak from around the brain. A negative result suggests the fluid is from another source, such as normal nasal mucus.
Who usually has this test
People with clear watery fluid dripping from the nose or ear, especially after a head injury or surgery.
Risks and aftercare
Collecting the fluid is not harmful; tell your doctor if you develop fever, headache or neck stiffness.
Names and options
Also called: beta 2 transferrin, CSF leak test
Listed by the hospital as
- BETA 2 TRANSFERRIN, CSF
Questions about this test
How much fluid is needed for a beta-2 transferrin test?
Only a small amount is needed, but enough must be collected for the lab. Your doctor will tell you how much and how to collect it.
Why does a CSF leak matter?
A leak creates a path between the outside and the brain's lining, which can raise the chance of meningitis. Finding it helps your doctor plan treatment.
Is a runny nose after a head injury always a CSF leak?
No. Most runny noses are normal mucus. This test helps tell whether the fluid is CSF.
Related tests
Tamara Hospital & IVF Centre, Rajajinagar
34/3, 10th Cross Road, opp. Vardhaka Sardar Patel School, 1st N Block, 2nd Stage, Rajajinagar, Bengaluru 560010
The hospital is open 24 hours. Call before you come to check the timing for your scan or sample collection.
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This page explains each test in general terms so you know what to expect. It is not medical advice: your doctor decides which tests you need and what your results mean. Reference ranges differ between laboratories. Updated 4 November 2026.