Islet cell antibody (IA-2 / ICA-512) test
Quick answer: This test looks for antibodies against IA-2 (also called ICA-512), a protein in the insulin-making cells of the pancreas. It helps doctors confirm type 1 or autoimmune diabetes, often together with a GAD65 antibody test.
- SampleBlood
- TakesAbout 5 minutes
- Before the testNo special preparation is usually needed.
How the test is done
- 1A small blood sample is taken from a vein
- 2The sample goes to a lab that runs islet antibody tests
- 3Antibodies against IA-2 are measured
- 4Your doctor compares the result with GAD65 and other results
What your results can mean
Reading your report
A positive result suggests autoimmune diabetes; discuss what it means with your doctor.
If the result is outside the usual range
A positive result can point to type 1 diabetes and is more common in children and young adults. Having several islet antibodies together suggests a higher chance of type 1 diabetes.
Who usually has this test
Children and adults with newly found diabetes where type 1 is suspected.
Risks and aftercare
Bruising is possible; keep checking your sugar as advised by your doctor.
Names and options
Also called: ICA-512, IA-2 antibody, islet antigen 2 antibody
Listed by the hospital as
- ISLET CELL ANTIBODY (ICA-512), SERUM
Questions about this test
Why test more than one islet antibody?
Each antibody is found in only some people with type 1 diabetes. Testing several together increases the chance of finding one.
How does IA-2 differ from GAD65?
IA-2 antibodies are more common in children and tend to appear closer to the start of diabetes. GAD65 antibodies are more common in adults with slow-onset forms.
Can a positive result change treatment?
It can help doctors judge whether insulin is likely to be needed early. Treatment is still based on your blood sugar and overall picture.
Related tests
Tamara Hospital & IVF Centre, Rajajinagar
34/3, 10th Cross Road, opp. Vardhaka Sardar Patel School, 1st N Block, 2nd Stage, Rajajinagar, Bengaluru 560010
The hospital is open 24 hours. Call before you come to check the timing for your scan or sample collection.
Get directions ↗IVF Pulse fertility care at Tamara Hospital →
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This page explains each test in general terms so you know what to expect. It is not medical advice: your doctor decides which tests you need and what your results mean. Reference ranges differ between laboratories. Updated 4 November 2026.