Anti-CCP antibody test
Quick answer: This blood test measures antibodies against cyclic citrullinated peptide (CCP), which are fairly specific for rheumatoid arthritis. Doctors usually order it with rheumatoid factor when you have joint pain or swelling and rheumatoid arthritis is suspected.
- SampleBlood
- TakesAbout 5 minutes
- Before the testNo special preparation is usually needed.
How the test is done
- 1You sit and roll up your sleeve
- 2A nurse cleans the skin and inserts a small needle
- 3One tube of blood is collected
- 4The lab measures CCP antibodies by immunoassay
What your results can mean
Reading your report
Ranges and cut-offs differ between labs and methods, so discuss your result with your doctor.
If the result is outside the usual range
A positive result, particularly a high level, can point to rheumatoid arthritis and can appear years before joints swell. It can also suggest a higher chance of joint damage, so doctors may treat earlier.
Who usually has this test
People with painful or swollen joints, morning stiffness or a positive rheumatoid factor.
Risks and aftercare
You may have a small bruise; carry on with your day as usual.
Names and options
Also called: anti-CCP, ACPA, cyclic citrullinated peptide antibody
Listed by the hospital as
- ANTI CCP
Questions about this test
Is anti-CCP better than rheumatoid factor?
Anti-CCP is more specific, meaning fewer false positives, while rheumatoid factor can be raised in many other conditions. Doctors often order both to get a fuller picture.
Can I have rheumatoid arthritis with a negative anti-CCP?
Yes. Some people have seronegative rheumatoid arthritis. Diagnosis rests on your joint findings, other blood tests and sometimes scans.
Can anti-CCP be positive before symptoms start?
Yes. It can be found years before arthritis develops. A positive result in someone without symptoms is usually watched rather than treated.
Related tests
Tamara Hospital & IVF Centre, Rajajinagar
34/3, 10th Cross Road, opp. Vardhaka Sardar Patel School, 1st N Block, 2nd Stage, Rajajinagar, Bengaluru 560010
The hospital is open 24 hours. Call before you come to check the timing for your scan or sample collection.
Get directions ↗IVF Pulse fertility care at Tamara Hospital →
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This page explains each test in general terms so you know what to expect. It is not medical advice: your doctor decides which tests you need and what your results mean. Reference ranges differ between laboratories. Updated 4 November 2026.