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Second opinion

Bring your numbers to someone who can see the rest

A calculator sees three or four figures. A specialist sees your history, your scans, your partner's results, and how you actually responded to treatment. If you're between cycles, changing clinics, or something in your results doesn't add up, a second opinion is the fastest way to find out whether anything would be done differently.

Free first consultation. No obligation to start treatment, and it doesn't affect your care at your current clinic.

‹ Embryology

Cleavage rate

Embryos progressing through the cleavage stage.

Exact calculationArithmetic on the numbers you enter. If your inputs are right, this figure is right.

inputCleaved embryos÷inputNormally fertilised (2PN)=resultCleavage rate (%)
In short

Cleavage rate is the proportion of fertilised embryos still dividing normally by day 3. Most units expect above 85%, because meaningful attrition usually appears later, between day 3 and the blastocyst stage.

Source — Most units expect the large majority of normally fertilised embryos to cleave. Meaningful attrition usually appears later, between day 3 and blastocyst.

Enter your values

Dividing normally on day 3

Fertilised on day 1

86%

That falls in the 85%+ band.

Cleaved embryos6
Normally fertilised (2PN)7

Where this sits

Your result of 86 % sits in the highlighted band. Bands are reference points used alongside clinical findings — not a diagnosis.

<70%70–85%85%+
Expected Borderline Below expected Worth discussing
85%+ %

Most fertilised embryos progressing normally, which is what is typically expected at this stage.

Most units expect the large majority of normally fertilised embryos to cleave. Meaningful attrition usually appears later, between day 3 and blastocyst.

Where this sits in the process
Planning
Testing
Cycle
Stimulation
Laboratory
After transfer

Highlighted is the stage this measurement belongs to. It is a map of the process, not a schedule — timings vary by protocol and by clinic.

Questions this usually raises

Is day 3 a good time to judge quality?

Only partly. Most embryos cleave; the informative attrition happens between day 3 and day 5. A good cleavage rate does not guarantee blastocysts.

Should we transfer on day 3?

If very few embryos are available, some units transfer earlier rather than risk none surviving to day 5. It is a genuine clinical judgement — ask what your unit would do and why.

My embryos cleaved but none reached blastocyst. Why?

Embryonic genome activation happens around day 3 — before that the embryo runs largely on maternal machinery. Arrest between day 3 and day 5 is where intrinsic embryo problems typically show, which is why the drop-off happens there and not earlier.

Or ask someone
  • A free first consultation covers this properly, with your actual results rather than an estimate
  • Both partners assessed together — male factor is involved in roughly half of cases

Related calculators

Second opinion

Bring your cleavage rate result to someone who can see the rest

A calculator sees three or four figures. A specialist sees your history, your scans, your partner's results, and how you actually responded to treatment. If you're between cycles, changing clinics, or something in your results doesn't add up, a second opinion is the fastest way to find out whether anything would be done differently.

Free first consultation. No obligation to start treatment, and it doesn't affect your care at your current clinic.

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Cleavage rate is a weaker quality signal than blastocyst conversion. Nothing here is a diagnosis or a substitute for assessment by a clinician.

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