Home / Calculators / Male fertility / DNA fragmentation (DFI)
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A calculator sees three or four figures. A specialist sees your history, your scans, your partner's results, and how you actually responded to treatment. If you're between cycles, changing clinics, or something in your results doesn't add up, a second opinion is the fastest way to find out whether anything would be done differently.
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These tools provide general information and are not a diagnosis or a substitute for assessment by a qualified clinician. Reference ranges and sources are stated on each calculator. Predictive estimates describe groups of people and cannot predict an individual outcome.
A calculator sees three or four figures. A specialist sees your history, your scans, your partner's results, and how you actually responded to treatment. If you're between cycles, changing clinics, or something in your results doesn't add up, a second opinion is the fastest way to find out whether anything would be done differently.
Free first consultation. No obligation to start treatment, and it doesn't affect your care at your current clinic.
What a DFI result means, and why a normal semen analysis does not rule it out.
Compared to published rangesYour values checked against published reference limits. The source is named below; laboratory methods vary.
The DNA fragmentation index measures the proportion of sperm with damaged DNA. Below 15% is generally considered low and above 30% high, though thresholds differ by assay method — a normal semen analysis does not rule out high fragmentation.
Source — DFI thresholds vary substantially between assay methods (SCSA, TUNEL, comet, halosperm). Confirm which method your laboratory used before comparing against any published threshold.
The bands on this page are drawn from published sources but have not yet been reviewed by our medical team, and some vary by laboratory or assay. Check against the reference range printed on your own report.
From your DFI report
That falls in the 15–25% band.
Your result of 18.0 % sits in the highlighted band. Bands are reference points used alongside clinical findings — not a diagnosis.
Intermediate. Often reported as a grey zone where the clinical significance is genuinely debated.
DFI thresholds vary substantially between assay methods (SCSA, TUNEL, comet, halosperm). Confirm which method your laboratory used before comparing against any published threshold.
Highlighted is the stage this measurement belongs to. It is a map of the process, not a schedule — timings vary by protocol and by clinic.
Because a standard analysis assesses count, movement and shape — not the DNA inside. Some men with entirely normal parameters have high fragmentation, and it is one explanation for unexplained failure.
Sometimes. Treating a varicocele or infection, stopping smoking, reducing heat exposure, and shorter abstinence intervals have all shown effects. Allow about three months for changes to appear, because of the production cycle.
No. Different assays produce different numbers for the same sample. The bands here are indicative — use your laboratory’s own reference range.
A calculator sees three or four figures. A specialist sees your history, your scans, your partner's results, and how you actually responded to treatment. If you're between cycles, changing clinics, or something in your results doesn't add up, a second opinion is the fastest way to find out whether anything would be done differently.
Free first consultation. No obligation to start treatment, and it doesn't affect your care at your current clinic.
DFI thresholds are assay-specific. Use the reference range from the laboratory that ran your test. Nothing here is a diagnosis or a substitute for assessment by a clinician.
A calculator gives you a number. These explain what it means, and what it does not.
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