IVF Reads / How to Boost Fertility Naturally: What Actually Has Evidence
How to Boost Fertility Naturally: What Actually Has Evidence
The ASRM 2022 committee opinion Optimizing Natural Fertility states: "In general, robust evidence is lacking that dietary and lifestyle interventions improve natural fertility, although dietary and lifestyle modifications may be recommended to improve overall health." The one natural measure with a live-birth benefit in a randomised trial is using urine ovulation tests to time intercourse: risk ratio 1.36 (95% CI 1.02 to 1.81), from 1 RCT of 844 participants at moderate certainty, in the 2023 Cochrane review of timed intercourse. Fertility-awareness methods showed no such benefit in the same review (RR 0.95, 95% CI 0.76 to 1.20).
- ASRM 2022 defines the fertile window as the six-day interval ending on the day of ovulation, with peak fecundability when intercourse occurs within two days before ovulation, and reports that approximately 80% of couples conceive in the first 6 months of trying — a cumulative figure.
- ASRM 2022 reports women who smoke were significantly more likely to be infertile (OR 1.60, 95% CI 1.34 to 1.91); two alcoholic drinks a day was associated with increased risk of infertility (RR 1.59, 95% CI 1.09 to 2.31); and high caffeine intake of 500 mg or more per day with reduced fertility (OR 1.45, 95% CI 1.03 to 2.04).
- In the LIFEstyle randomised trial (NEJM 2016), 577 women with a BMI of 29 or higher were assigned to a 6-month lifestyle programme before infertility treatment or to prompt treatment. The programme achieved more weight loss (4.4 kg versus 1.1 kg) yet produced fewer healthy term vaginal births within 24 months: 27.1% versus 35.2%, rate ratio 0.77 (95% CI 0.60 to 0.99).
- In the FAZST trial (JAMA 2020), 2,370 men took folic acid with zinc or placebo for six months: live birth occurred in 34% versus 35% of couples (risk difference -0.9%, 95% CI -4.7% to 2.8%), semen parameters did not differ, and sperm DNA fragmentation was higher on supplementation (29.7% versus 27.2%, mean difference 2.4%).
- ASRM 2022 states there is little evidence that dietary variations such as vegetarian diets, low-fat diets, vitamin-enriched diets, antioxidants or herbal remedies improve fertility in women without ovulatory dysfunction.
Which natural changes actually improve the chance of pregnancy?
Three things have measured numbers behind them: timing intercourse to the fertile window using urine ovulation tests, stopping tobacco, and not drinking daily. Almost everything else sold as natural fertility support — herbal remedies, detoxes, fertility diets, hydration targets — has either been tested and failed, or never been tested at all.
That is not this page's opinion. It is what the guideline written for exactly this question says. The American Society for Reproductive Medicine's 2022 committee opinion, Optimizing Natural Fertility, states: "In general, robust evidence is lacking that dietary and lifestyle interventions improve natural fertility, although dietary and lifestyle modifications may be recommended to improve overall health."
Read that carefully, because it is doing two things at once. It is not saying eating well is pointless. It is saying the reason to eat well is your health, and that the extra promise attached to it — that it will get you pregnant — is not supported. Those are different claims, and the second one is the one being sold.
What has been measured, and with what numbers?
Four items on the usual list have effect sizes attached. They are not equivalent to each other, and none of them is large.
Timing. ASRM 2022 defines the fertile window, for counselling purposes, as the six-day interval ending on the day of ovulation, with peak fecundability when intercourse occurs within two days before ovulation. The 2023 Cochrane review of timed intercourse pooled 7 randomised trials and 2,464 women or couples. Using urine ovulation tests probably increases live birth, risk ratio 1.36 (95% CI 1.02 to 1.81). Fertility-awareness methods — temperature charting, mucus monitoring, calendar and app tracking — showed no such benefit, risk ratio 0.95 (95% CI 0.76 to 1.20). Whether an app is enough is covered separately in how reliable fertility apps actually are.
Tobacco. ASRM 2022 reports that women who smoke were significantly more likely to be infertile, odds ratio 1.60 (95% CI 1.34 to 1.91). ASRM issued a new committee opinion in 2024 covering tobacco, nicotine and marijuana, which replaces its 2018 smoking opinion — so if you are reading older advice on this, it has been superseded.
There is an India-specific problem with the word smoking. WHO India reports tobacco use prevalence at nearly 267 million adults, about 29% of all adults, and states that the most prevalent form of tobacco use in India is smokeless — khaini, gutkha, betel quid with tobacco, zarda. Advice framed only around cigarettes misses most Indian tobacco users. The honest position is that the measured association is with tobacco and nicotine, and that quitting is worth doing whichever form you use.
Alcohol. ASRM 2022 reports that among women who consumed two alcoholic drinks per day, the risk of infertility was significantly increased, relative risk 1.59 (95% CI 1.09 to 2.31). That is a threshold, not a statement about any drinking at all.
Caffeine. ASRM 2022 associates high caffeine consumption — 500 mg, more than five cups of coffee per day — with decreased fertility, odds ratio 1.45 (95% CI 1.03 to 2.04). This matters in the other direction from how it is usually presented: the threshold is high. Ordinary tea drinking is nowhere near it, and there is no retrieved basis for telling someone trying to conceive to give up chai.
Should we get weight down before starting treatment?
This one has been randomised, and the answer surprised the people who ran it.
The LIFEstyle trial, published in the New England Journal of Medicine in 2016, took 577 infertile women with a body mass index of 29 or higher. One group did a six-month lifestyle programme first and then had up to 18 months of infertility treatment. The other went straight to 24 months of treatment. The programme worked on the thing it was aiming at: mean weight loss was 4.4 kg against 1.1 kg in the control group.
The birth outcome went the other way. A healthy singleton born vaginally at term within 24 months occurred for 27.1% of the lifestyle-first group versus 35.2% of the prompt-treatment group, a rate ratio of 0.77 (95% CI 0.60 to 0.99). Fewer healthy babies, not more.
Be careful what you take from that. The trial did not test whether weight affects fertility; it tested a strategy of spending six months on weight before starting treatment. What it establishes is that the delay has a cost, and that the cost can exceed the benefit. If a clinic asks you to lose weight before it will treat you, this is the trial to ask them about.
Do supplements or herbal remedies improve fertility?
ASRM 2022 answers this directly, and names the categories: "there is little evidence that dietary variations, such as vegetarian diets, low-fat diets, vitamin-enriched diets, antioxidants, or herbal remedies, improve fertility in women without ovulatory dysfunction."
The two Cochrane reviews are worth reading past their headlines. For women, the 2020 review covered 63 trials and 7,760 women; the live birth odds ratio was 1.81 (95% CI 1.36 to 2.43), but the certainty was graded very low and the reviewers' own wording is "we are uncertain whether antioxidants improve live birth rate". An impressive odds ratio at very low certainty is not a finding you can act on.
For men, the 2022 review covered 90 trials and 10,303 subfertile men. Live birth odds ratio 1.43 (95% CI 1.07 to 1.91), very low certainty. When the trials at high risk of bias were removed, the effect disappeared: Peto odds ratio 1.22 (95% CI 0.85 to 1.75), across 827 men in 8 trials. The same review found antioxidants may increase mild gastrointestinal discomfort, odds ratio 2.70 (95% CI 1.46 to 4.99).
The largest properly randomised test of the two nutrients sold hardest for male fertility found nothing. In the FAZST trial, 2,370 men took 5 mg folic acid with 30 mg zinc or placebo for six months. Live birth occurred for 34% versus 35% of couples, risk difference -0.9% (95% CI -4.7% to 2.8%). No semen parameter improved. Sperm DNA fragmentation was significantly higher on supplementation, 29.7% versus 27.2%, mean difference 2.4% (95% CI 0.5% to 4.4%).
One supplement recommendation is real and is routinely misdescribed. ASRM 2022 advises women attempting conception to take at least 400 micrograms of folic acid daily. That is to reduce the risk of neural tube defects in a pregnancy, not to help you get pregnant. Take it; do not expect it to shorten the wait. The supplement question in more depth is covered in what couple-friendly fertility supplements actually do, and the herbal and Ayurvedic side of it in whether Ayurveda has been tested for infertility.
Not sure whether to keep trying or get tested?
IVY can read your reports alongside your history and set out what the evidence supports for your situation, and what it does not.
How long before a change could show?
On the male side there is a real biological clock on this, and it is about three months. A cycle of human spermatogenesis was estimated at roughly 64 days in the classic 1963 measurement, and with transit through the epididymis on top, the sperm in any given sample were made some ten to twelve weeks ago. So a man who stops tobacco today cannot expect a different semen analysis next month. Repeat the test at three months or do not repeat it at all.
On the female side there is no equivalent measured lag, and you should be suspicious of anyone who gives you one. Nothing retrieved here establishes how long a dietary or activity change takes to alter the chance of conceiving, because no trial has shown that such a change alters it in the first place.
What does have a timescale is the decision. ASRM's cumulative figure of approximately 80% of couples conceiving within the first six months is the honest anchor: if six months of well-timed attempts have passed, the useful next step is testing, not another supplement. The sequence of decisions is set out in how to build a fertility plan that commits to something.
When is "natural" the wrong place to put the effort?
Sometimes the answer is testing, timing or a simpler treatment, and sometimes lifestyle is not the lever at all.
Notice the qualifier in the ASRM sentence quoted above: little evidence of benefit in women without ovulatory dysfunction. It cuts both ways. Where ovulation is genuinely disordered, ASRM allows that a healthy lifestyle may help — so irregular or absent periods are a reason to be investigated, not a reason to try harder at diet.
Blocked tubes, severe male factor and age are not lifestyle problems and do not respond to lifestyle answers. Neither does an undiagnosed cause. The cost of natural-first is always time, and the LIFEstyle result is the measured version of what that time can cost.
Two adjacent questions have their own pages, both with the figures attached: which male lifestyle factors have measured effect sizes and whether stress actually stops you getting pregnant.
What the evidence does not establish
This is the most useful section on a page like this, so it is stated plainly rather than buried.
- That any diet improves fertility. ASRM 2022 states robust evidence is lacking for dietary and lifestyle interventions improving natural fertility. No retrieved trial shows a fertility diet raising the chance of a live birth.
- That herbal remedies do anything. Not one of the seven herbs named on the earlier version of this page had retrievable trial evidence for a fertility outcome. Absence of evidence is not proof they fail — it means nobody knows, which is not what the label implies.
- That hydration matters. No retrieved source supports a water target for fertility, cervical mucus, egg quality or semen volume. The claim has been removed rather than softened.
- That antioxidants raise live births. Both Cochrane reviews are graded very low certainty, and the male signal disappears once high risk-of-bias trials are excluded.
- That losing weight raises your own chance of a baby. The LIFEstyle trial tested a strategy in women with a BMI of 29 or higher and found the lifestyle-first arm did worse on healthy term births. It cannot tell an individual what her own weight change would do.
- That the alcohol, caffeine and smoking figures are causal. They are associations reported in a guideline, drawn from observational work. They are strong enough to act on and not strong enough to call proof.
- Indian applicability. Every effect size on this page comes from North American or European populations. No Indian trial of any of these interventions was retrieved, and the smokeless tobacco point is an inference from WHO India prevalence data rather than a measured Indian fertility outcome.
One honest note
Almost everything in the natural fertility market is sold on the idea that there is something you have not done yet. For most people reading this there is not, and the waiting is the hard part rather than a sign you are getting it wrong. Timing well, stopping tobacco, drinking little, and getting tested at six months is close to the whole evidence-backed list, and it is short on purpose.
Keep reading
9 Sources
- Practice Committee of the American Society for Reproductive Medicine and the Practice Committee of the Society for Reproductive Endocrinology and Infertility. Optimizing natural fertility: a committee opinion. Fertility and Sterility 2022;117(1):53-63. PMID 34815068. Retrieved and read 28 Sep 2026. Source of the statement that robust evidence is lacking that dietary and lifestyle interventions improve natural fertility; the definition of the fertile window as the six-day interval ending on the day of ovulation; peak fecundability within two days before ovulation; intercourse every 1-2 days in the fertile window versus 2-3 times per week; approximately 80% of couples conceiving in the first 6 months; smoking OR 1.60 (95% CI 1.34-1.91); two drinks per day RR 1.59 (95% CI 1.09-2.31); caffeine 500 mg or more OR 1.45 (95% CI 1.03-2.04); the 400 microgram folic acid recommendation; and the sentence naming vegetarian diets, low-fat diets, vitamin-enriched diets, antioxidants and herbal remedies as having little evidence of fertility benefit in women without ovulatory dysfunction. Fertility and Sterility (ASRM)
- Gibbons T, Reavey J, Georgiou EX, Becker CM. Timed intercourse for couples trying to conceive. Cochrane Database of Systematic Reviews 2023;9:CD011345. PMID 37709293. Source of the 7 randomised trials and 2,464 women or couples; urinary ovulation detection live birth RR 1.36 (95% CI 1.02-1.81) from 1 RCT of 844 participants at moderate certainty, with the 16% to 28% absolute framing; and fertility-awareness methods live birth RR 0.95 (95% CI 0.76-1.20). Cochrane Database of Systematic Reviews
- Mutsaerts MA, van Oers AM, Groen H, et al. Randomized Trial of a Lifestyle Program in Obese Infertile Women. New England Journal of Medicine 2016;374(20):1942-1953. PMID 27192672 (the LIFEstyle trial). An erratum was published at NEJM 2018;378(26):2546; its content was not retrieved. Source of the 577 randomised women with BMI 29 or higher, mean weight loss 4.4 kg versus 1.1 kg, and the primary outcome of a healthy term singleton born vaginally within 24 months occurring in 27.1% versus 35.2%, rate ratio 0.77 (95% CI 0.60-0.99). New England Journal of Medicine
- Showell MG, Mackenzie-Proctor R, Jordan V, Hart RJ. Antioxidants for female subfertility. Cochrane Database of Systematic Reviews 2020;8:CD007807. PMID 32851663. Source of the 63 trials and 7,760 women, the live birth odds ratio of 1.81 (95% CI 1.36-2.43) graded very low certainty, and the reviewers' own statement that they are uncertain whether antioxidants improve live birth rate. Cochrane Database of Systematic Reviews
- de Ligny W, Smits RM, Mackenzie-Proctor R, et al. Antioxidants for male subfertility. Cochrane Database of Systematic Reviews 2022;5:CD007411. PMID 35506389. Source of the 90 trials and 10,303 subfertile men, live birth odds ratio 1.43 (95% CI 1.07-1.91) at very low certainty, its disappearance when high risk-of-bias trials are removed (Peto OR 1.22, 95% CI 0.85-1.75, 827 men, 8 RCTs), and the increase in mild gastrointestinal discomfort (OR 2.70, 95% CI 1.46-4.99). Cochrane Database of Systematic Reviews
- Schisterman EF, Sjaarda LA, Clemons T, et al. Effect of Folic Acid and Zinc Supplementation in Men on Semen Quality and Live Birth Among Couples Undergoing Infertility Treatment: A Randomized Clinical Trial. JAMA 2020;323(1):35-48. PMID 31910279 (FAZST). Correction at JAMA 2020;323(12):1194, retrieved: two rows of baseline Table 1 (multivitamin use within the past 3 months) were transposed between groups; the outcome data are unaffected. Source of the 2,370 randomised men, live birth 34% versus 35% (risk difference -0.9%, 95% CI -4.7% to 2.8%), unchanged semen parameters, higher DNA fragmentation on supplementation (29.7% versus 27.2%, mean difference 2.4%, 95% CI 0.5% to 4.4%), and the excess of gastrointestinal symptoms. JAMA
- Practice Committee of the American Society for Reproductive Medicine. Tobacco or marijuana use and infertility: a committee opinion. Fertility and Sterility 2024;121(4):589-603. PMID 38284953. Erratum at Fertility and Sterility 2024;122(2):393. Source of the fact that this document replaces the 2018 ASRM Smoking and Infertility committee opinion and that its scope covers tobacco, nicotine and marijuana rather than cigarettes alone. Abstract retrieved; full text not retrieved, so no effect estimate is attributed to it on this page. Fertility and Sterility (ASRM)
- World Health Organization, Country Office for India — Tobacco health topic. Source of the figure of nearly 267 million adults, about 29% of all adults, using tobacco in India, and of the statement that the most prevalent form of tobacco use in India is smokeless tobacco, including khaini, gutkha, betel quid with tobacco and zarda. Retrieved 28 Sep 2026. The page does not give a smoking/smokeless percentage split, so none is quoted. World Health Organization (India)
- Heller CG, Clermont Y. Spermatogenesis in man: an estimate of its duration. Science 1963;140(3563):184-186. PMID 13953583. Source of the roughly 64-day duration of a cycle of human spermatogenesis, behind the statement that a change on the male side needs about three months before a repeat semen analysis is meaningful. Science
Frequently asked questions
Common questions on this topic.
Is it better to have intercourse every day or every other day?
ASRM's 2022 committee opinion states that intercourse every 1 to 2 days during the fertile window yields the highest pregnancy rates, and that results achieved with less frequent intercourse of 2 to 3 times per week are nearly equivalent. So daily is not required, and the difference between every-other-day and a couple of times a week is small enough that it should not be a source of argument.
Can a tracking app replace ovulation test strips?
Not on the evidence in the 2023 Cochrane review. Urine ovulation tests probably increase live birth compared with no ovulation prediction, risk ratio 1.36 (95% CI 1.02 to 1.81). Fertility-awareness methods, which include calendar charting and tracking apps, showed no benefit in the same review, risk ratio 0.95 (95% CI 0.76 to 1.20), on low-quality evidence. That is a difference in what has been demonstrated, not proof that apps cannot work.
Are fertility supplements harmful, or just useless?
The retrieved harms are modest but real. The 2022 Cochrane review of antioxidants for male subfertility found they may increase mild gastrointestinal discomfort, odds ratio 2.70 (95% CI 1.46 to 4.99) across 1,355 men. In the FAZST trial of 2,370 randomised men, abdominal discomfort, nausea and vomiting were all more common on folic acid with zinc than placebo, and sperm DNA fragmentation was higher on supplementation. The cost is usually money and false reassurance rather than injury.
Does losing weight help if my periods are irregular?
Possibly, and this is the one place ASRM 2022 is more encouraging. Its statement that there is little evidence of a dietary or lifestyle fertility benefit is specifically about women without ovulatory dysfunction, and it allows that a healthy lifestyle may help to improve fertility in women with ovulatory dysfunction. Irregular or absent periods are a reason to be assessed, because the answer depends on the cause.
Does any of this apply to smokeless tobacco?
The measured fertility associations in ASRM's opinions are largely built on smoking. ASRM's 2024 committee opinion widens the scope to tobacco, nicotine and marijuana and replaces its 2018 smoking document, but no retrieved source gives a separate effect size for khaini, gutkha or similar products against a fertility outcome. Since WHO India reports smokeless tobacco as the most prevalent form of tobacco use in India, this is a real and unmeasured gap rather than a reason to assume it is safe.

